Immunocompromising conditions qualifying for second COVID booster

• Cancer - Non-haematological cancer including those diagnosed within the past 5 years or on chemotherapy, radiotherapy, immunotherapy or targeted anti-cancer therapy (active treatment or recently completed) or with advanced disease regardless of treatment. Survivors of childhood cancer.

• Chronic inflammatory conditions requiring medical treatment with disease modifying anti-rheumatic drugs (DMARDs) or immune-suppressive or immunomodulatory therapies.

• Systemic lupus erythematosus, rheumatoid arthritis, Crohn’s disease, ulcerative colitis, and similar who are being treated.

• Chronic lung disease - Chronic obstructive pulmonary disease, cystic fibrosis, interstitial lung disease and severe asthma (defined as requiring frequent hospital visits or the use of multiple medications).

• Chronic liver disease - Cirrhosis, autoimmune hepatitis, non-alcoholic fatty liver disease, alcoholic liver disease.

• Severe chronic kidney disease (stage 4 or 5)

• Chronic neurological disease - Stroke, neurodegenerative disease (e.g dementia, motor neurone disease, Parkinson’s disease), myasthenia gravis, multiple sclerosis, cerebral palsy, myopathies, paralytic syndromes, epilepsy.

• Diabetes mellitus requiring medication

• Chronic cardiac disease

• Ischaemic heart disease, valvular heart disease, congestive cardiac failure, cardiomyopathies, poorly controlled hypertension, pulmonary hypertension, complex congenital heart disease.

• People with disability with significant or complex health needs or multiple comorbidities which increase risk of poor outcome from COVID-19, particularly those with trisomy 21 (Down Syndrome) or complex multi-system disorders.

• Severe obesity with BMI ≥ 40 kg/m2

• Severe underweight with BMI < 16.5 kg/m2